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Title of article :
Protective effects of a polysaccharide from Hizikia fusiformis against ethanol toxicity in rats
Author/Authors :
Choi، نويسنده , , Eun Young and Hwang، نويسنده , , Hye-Jeong and Kim، نويسنده , , Hye Jin Nam، نويسنده , , Taek-Jeong، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Pages :
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Abstract :
Hizikia fusiformis is an edible brown alga that is widely consumed in Korea, Japan, and China and possesses a number of potentially beneficial compounds, including antioxidants and anticoagulants. No reports have investigated potential H. fusiformis protectants against ethanol-induced peptic injury. We extracted a polysaccharide from H. fusiformis (Hf–PS-1) that exhibited protective effects against ethanol-induced peptic injury and related mechanisms in rats. Experimental animals were divided into three groups: control, ethanol-only, and ethanol + Hf–PS-1. The ethanol-only group exhibited decreased levels of total glutathione (GSH) and increased levels of jun N-terminal kinase (JNK) phosphorylation relative to the control group, whereas levels were significantly increased and decreased, respectively, in the ethanol + Hf–PS-1 group. The ethanol-only group also exhibited increased levels of extracellular signal-regulated kinase 1/2 (ERK 1/2) phosphorylation relative to the control group; these levels were not significantly different in the ethanol + Hf–PS-1 group. Hf–PS-1 appeared to reduce ethanol-induced gastric injury. Therefore, we suggest that Hf–PS-1 could protect against ethanol-induced peptic ulcers primarily through a mechanism associated with the inhibition of JNK activation.
Keywords :
SEAWEED , polysaccharide , Hizikia fusiformis , Protectant , JNK
Journal title :
Food and Chemical Toxicology
Journal title :
Food and Chemical Toxicology
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