Record number :
2117554
Title of article :
Inhibition of nicotine-DNA adduct formation in mice by six dietary constituents
Author/Authors :
Cheng، نويسنده , , Y. and Li، نويسنده , , H.L. and Wang، نويسنده , , H.F. and Sun، نويسنده , , H.F. and Liu، نويسنده , , Y.F. and Peng، نويسنده , , S.X. and Liu، نويسنده , , K.X. and Guo، نويسنده , , Z.Y.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Pages :
6
From page :
1045
To page :
1050
Abstract :
Nicotine [3-(1-methyl-2-pyrrolidinyl)-pyridine] is a major alkaloid in tobacco products and has proven to be a potential genotoxic compound. Many natural dietary products can suppress the DNA adduction, and hence act as inhibitors of cancer. In this study, we investigated the inhibitory effects of curcumin, garlic squeeze, grapeseed extract, tea polyphenols, vitamin C, and vitamin E on nicotine-DNA adduction in vivo using an ultrasensitive method of accelerator mass spectrometry (AMS). The results demonstrated that all the dietary constituents induced marked dose-dependent decrease in nicotine-DNA adducts as compared with the control. The reduction rate reached about 50% for all agents, except garlic squeeze (40%), even at its highest dose level. Amongst the six agents, grapeseed extract exhibited the strongest inhibition to the DNA adduct formation. Therefore, we may arrive at a point that these dietary constituents are beneficial to prevent the harmful adduct formation, and thus to block the potential carcinogenesis induced by nicotine.
Keywords :
Inhibition , Dietary constituents , AMS , nicotine , DNA adducts
Journal title :
Food and Chemical Toxicology
Journal title :
Food and Chemical Toxicology
Serial Year :
2003
Link To Document :
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