Title of article :
Loss of naïve (CD45RA+) CD4+ lymphocytes during pediatric infection with feline immunodeficiency virus
Carreٌo، نويسنده , , Abigail D. and Mergia، نويسنده , , Ayalew and Novak، نويسنده , , Janelle and Gengozian، نويسنده , , Nazareth and Johnson، نويسنده , , Calvin M.، نويسنده ,
Feline immunodeficiency virus (FIV) infection of cats is an animal model for the pathogenesis of CD4+ lymphopenia and thymus dysfunction in HIV-infected humans. Recently, a monoclonal antibody (755) was reported to recognize the feline homologue to CD45RA, allowing the enumeration of naïve T cells in cats. We tested the hypothesis that pediatric FIV infection would be associated with a selective loss of naïve CD4+ lymphocytes by inoculating newborn cats with a pathogenic clone of FIV (JSY3) or a related clone with an inactive ORF-A gene (JSY3-ΔORFA), and compared the data to age-matched uninfected control cats. Both FIV inocula were associated with a reduction in the CD4–CD8 ratio (p = 0.01), which was attributable to a disproportionate loss of naïve CD4+ cells (p = 0.01) vs. naïve CD8+ cells. Therefore, the reduced CD4:CD8 ratio in FIV-infected juvenile cats is associated with a selective depletion of naïve CD4+ cells from the blood.
FIV , Naïve CD4 lymphocytes , CD45RA , HIV
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