وصوقي نيا، حسن نويسنده Gastroenterologist, Department of Gastroenterology and Hepatology, Mashhad University of Medical Sciences, Mashhad, Iran , , آل داوود، سيد امير نويسنده Oncologist, Department of Radiotherapy and Oncology, Mashhad University of Medical Sciences, Mashhad, Iran , , غفارزاده گان، كامران نويسنده , , شاكري، محمد تقي نويسنده shakeri, mohammad taghi , شريفان، رامين نويسنده استاديار دانشكده پزشكي دانشگاه آزاد اسلامي واحد مشهد Sharifan, Ramin , عابديني، سياوش نويسنده Student of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran , , مختاري اميرمجدي، الهام نويسنده Gastroenterologist, Gastroenterology and Hepatology, Nayshabour Faculty of Medical Sciences, Nayshabour, Iran ,
Introduction: Esophageal Squamous-Cell Carcinoma (SCC) is one of the
most common malignancies in Iran. To reduce the incidence of esophageal
SCC, it is important to recognize the controllable risk factors and prevent
them. Celiac disease is widely known as a possible risk factor for esophageal
SCC. Thus, we decided to assess the frequency of celiac disease in
esophageal SCC patients in North east of Iran in order to suggest correlation
between two diseases.
Materials and Methods: In a Cross-sectional study one hundred and fortythree
cases of esophageal SCC were examined for anti tissue
transglutaminase antibody (anti-tTG) between the years 2004 and 2009 in
Ghaem and Omid Hospitals of Mashhad University of Medical Sciences, Iran.
The enzyme-linked immunosorbent assay was the test of choice in this
study since it provides the sensitivity and specificity needed for the
diagnosis and screening of celiac disease. The results of this test were
compared with those of the control group which were compatible in terms
of sex and age. Data were analyzed through SPSS software and statistical
analysis such as x2, exact x2 and T-test.
Results: 19.6% patients (SCC) had positive anti-tTG ( > 20) which was
significantly different to 7.9% in control group (p -value=0.005).
Comparing age groups of patients for positive anti_tTG using exact x
square test showed significant difference in patients with < 40 years old (P
Conclusion: There seems to be a correlation between positive anti_tTG
and esophageal SCC; that is to say, celiac disease might play a role in the
earlier manifestations of esophageal SCC.