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Title of article :
Size-controlled biodegradable nanoparticles: Preparation and size-dependent cellular uptake and tumor cell growth inhibition
Author/Authors :
Choi، نويسنده , , Jin-Seok and Cao، نويسنده , , Jiafu and Naeem، نويسنده , , Muhammad and Noh، نويسنده , , Jinki and Hasan، نويسنده , , Nurhasni and Choi، نويسنده , , Hoo-Kyun and Yoo، نويسنده , , Jin-Wook، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Pages :
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Abstract :
Biodegradable nanoparticles with diameters below 1000 nm are of great interest in the contexts of targeted delivery and imaging. In this study, we prepared PLGA nanoparticles with well-defined sizes of ∼70 nm (NP70), ∼100 nm (NP100), ∼200 nm (NP200), ∼400 nm (NP400), ∼600 nm (NP600) and ∼1000 nm (NP1000) using facile fabrication methods based on a nanoprecipitation and solvent evaporation techniques. The nanoparticles showed a narrow size distribution with high yield. Then the size-controlled biodegradable nanoparticles were used to investigate how particle size at nanoscale affects interactions with tumor cells and macrophages. Interestingly, an opposite size-dependent interaction was observed in the two cells. As particle size gets smaller, cellular uptake increased in tumor cells and decreased in macrophages. We also found that paclitaxel (PTX)-loaded nanoparticles showed a size-dependent inhibition of tumor cell growth and the size-dependency was influenced by cellular uptake and PTX release. The size-controlled biodegradable nanoparticles described in this study would provide a useful means to further elucidate roles of particle size on various biomedical applications.
Keywords :
Tumor cell growth inhibiton , Particle size , cellular uptake , Biodegradable nanoparticles
Journal title :
Colloids and Surfaces B Biointerfaces
Journal title :
Colloids and Surfaces B Biointerfaces
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