Record number :
1967640
Title of article :
Blood compatibility of surface-engineered poly(ethylene terephthalate) via o-carboxymethylchitosan
Author/Authors :
Aiping، نويسنده , , ZHU Qing-tian، نويسنده , , Chen، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
6
From page :
120
To page :
125
Abstract :
Poly(ethylene terephthalate) (PET) films were treated by argon plasma following by graft copolymerization with acrylic acid (AAc). The obtained PET-surface grafted PAA (PET-g-PAA) was coupled with chitosan (CS) and o-carboxymethylchitosan (OCMCS) molecules, respectively. Their surface physicochemical properties were characterized by X-ray photoelectron spectroscopy (XPS), water contact angle and streaming potential measurements. The PET-g-PAA surface containing carboxylic acid, CS immobilized PET surface containing amino and OCMCS immobilized PET surface containing both carboxylic acid and amino groups, make the PET surface exhibited a hydrophilic character. The blood compatibility was evaluated by platelet contacting experiments and protein adsorption experiments in vitro. The results demonstrate that the PET surface coupling OCMCS shows much less platelet adhesive and fibrinogen adsorption compared to the other surface modified PET films. The anticoagulation of PET-OCMCS is ascribed to the suitable balance of hydrophobicity/hydrophilicity, surface zeta potential and the low adsorption of protein.
Keywords :
Chitosan , Fibrinogen adsorption , Poly(ethylene terephthalate) , Blood compatibility , O-Carboxymethylchitosan
Journal title :
Colloids and Surfaces B Biointerfaces
Serial Year :
2006
Link To Document :
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