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Title of article :
Beneficial effects of fucoidan on osteoblastic MG-63 cell differentiation
Author/Authors :
Cho، نويسنده , , Young-Sook and Jung، نويسنده , , Won-Kyo and Kim، نويسنده , , Jung Ae and Choi، نويسنده , , IL-Whan and Kim، نويسنده , , Se-Kwon، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Pages :
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Abstract :
Fucoidan extracted from the marine brown alga Undaria pinnatifida, significantly induced osteoblastic cell differentiation. Our results indicated that a non-toxic sulphated polysaccharide, fucoidan, can increase activity of alkaline phosphatase (ALP) and level of osteocalcin (OC) as phenotypic markers for early-stage osteoblastic differentiation and terminally osteoblastic differentiation, respectively. Furthermore, the results showed positive effects of fucoidan on bone morphogenic protein-2 (BMP-2) as an important factor for bone formation, remodeling and mineralization. The present study may provide new insights in the osteoblastic differentiation of fucoidan and possibility for its application in bone health supplement.
Keywords :
Alkaline phosphatase (ALP) , Bone morphogenetic protein-2 (BMP-2) , Osteocalcin (OC) , fucoidan , osteoblastic differentiation
Journal title :
Food Chemistry
Journal title :
Food Chemistry
Serial Year :
Link To Document :