Cheng، نويسنده , , Yi-Chang and Chang، نويسنده , , Mu-Hsin and Tsai، نويسنده , , Cheng-Chih and Chen، نويسنده , , Tung-Sheng and Fan، نويسنده , , Chung-Chen and Lin، نويسنده , , Chien-Chung and Lai، نويسنده , , Chao-Hung and Tsai، نويسنده , , Fuu-Jen and Lin، نويسنده , , James A. and Huang، نويسنده , , Chih-Yang، نويسنده ,
Hypercholesterolemia is a well established risk factor for cardiac cell apoptosis. The purpose of this study is to evaluate the effects of garlic oil on cardiac apoptosis induced by a hypercholesterol diet.
-four male Golden-Syrian hamsters at 3 months of age were randomly divided into three groups, control, cholesterol and garlic oil groups received a chow diet, chow diet with 2% cholesterol, and chow diet with 2% cholesterol and 1% garlic oil for 8 weeks, respectively.
NEL-positive apoptotic cells, and several apoptotic proteins were significantly induced in the excised left ventricle in cholesterol group, whereas significant reduction was observed in cholesterol plus garlic oil group. The IGFI receptor dependent survival pathway was inhibited in cholesterol group whereas it was obviously reversed in cholesterol plus garlic oil group. Our results suggest that administration of garlic oil shows protective effects on cardiac apoptosis in rats with high cholesterol intake.
Hypercholesterolemia , Cardiac apoptosis , Garlic oil , Cardiac survival