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Title of article :
Effects of Hemoglobin Concentration and Creatinine Clearance in Pro-B-Type Natriuretic Peptide-Based Left Ventricular Filling Pressure Prediction in Patients With Preserved Left Ventricular Systolic Function
Author/Authors :
Choi، نويسنده , , Eui-Young and Ha، نويسنده , , Jong-Won and Joung، نويسنده , , Boyoung and Ko، نويسنده , , Young-Guk and Choi، نويسنده , , Donghoon and Rim، نويسنده , , Se-Joong and Jang، نويسنده , , Yangsoo and Chung، نويسنده , , Namsik and Shim، نويسنده , , Won-Heum and Cho، نويسنده , , Seung-Yun، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
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Abstract :
Although N-terminal pro–B-type natriuretic peptide (pro-BNP) has been shown to correlate with left ventricular (LV) filling pressure, pro-BNP-based LV filling pressure prediction has some limitations due to several factors that affect pro-BNP. The aim of this study was to evaluate the effects of blood hemoglobin concentration and creatinine clearance (CCr) on pro-BNP-based LV filling pressure prediction in patients with preserved LV systolic function. A total of 421 consecutive patients referred for coronary angiography underwent LV pressure measurement by fluid-filled catheters. Patients with plasma creatinine levels ≥1.5 mg/dl and LV ejection fractions <50% were excluded. LV diastolic pressures and echocardiographic parameters were compared with pro-BNP levels in 281 patients. Blood hemoglobin levels and CCr were measured simultaneously. Log pro-BNP was independently correlated with hemoglobin concentration (β = −0.261, p <0.001), CCr (β = −0.230, p <0.001) and LV pre-A-wave pressure (β = 0.384, p <0.001). A pro-BNP level of 124 pg/ml was the optimal cutoff for LV pre-A-wave pressure >15 mm Hg in all patients (sensitivity 67%, specificity 67%, p <0.001). However, by subclassification according to hemoglobin and CCr tertiles, optimal cut-off values varied significantly, and their predictive accuracies could be improved (from 89 to 331 pg/dl, with diagnostic accuracy up to 79%). In conclusion, in the pro-BNP-based prediction of elevated LV filling pressure, subclassification on the basis of hemoglobin concentration and CCr should be considered in patients with preserved LV systolic and renal function.
Journal title :
American Journal of Cardiology
Journal title :
American Journal of Cardiology
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