Record number :
Title of article :
Insulin-like growth factor pathway: A link between androgen deprivation therapy (ADT), insulin resistance, and disease progression in patients with prostate cancer?
Author/Authors :
Aggarwal، نويسنده , , Rahul R. and Ryan، نويسنده , , Charles J. and Chan، نويسنده , , June M.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
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Abstract :
Androgen deprivation therapy (ADT) is standard of care for patients with metastatic hormone-sensitive prostate cancer (HSPC), yet through its induction of a hypogonadal state leads to metabolic perturbations, including insulin resistance (IR) and obesity. IR and obesity have been associated with an increased risk of progression to castrate-resistant prostate cancer (CRPC) and ultimately increased prostate cancer-specific mortality. On a molecular level, this association between obesity/IR and prostate cancer progression may be mediated by alterations in the insulin-like growth factor (IGF) axis, which has been shown to be up-regulated upon disease progression to CRPC. Targeting the IGF axis, either by anti-IGF therapy or via enhancement of peripheral insulin sensitivity, represents a viable therapeutic target in patients with prostate cancer. Using the development of IR and/or obesity may represent a clinically available biomarker that may predict those patients most likely to respond to such therapy, and warrants testing in future prospective clinical trials.
Keywords :
Castration-resistant , Insulin resistance , prostate cancer , Androgen deprivation therapy , Insulin-Like Growth Factor
Journal title :
Urologic Oncology
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Link To Document :