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Title of article :
DABCO catalyzed highly regioselective synthesis of fused imidazo-heterocycles in aqueous medium
Author/Authors :
Bangade، نويسنده , , Vikas M. and Reddy، نويسنده , , B. Chennakesava and Thakur، نويسنده , , Pramod B. and Madhu Babu، نويسنده , , B. and Meshram، نويسنده , , H.M.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
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Abstract :
An efficient regioselective synthesis of 3-aryl imidazo[1,2-a]pyridines, 5-aryl imidazo[2,1-b]thiazoles, and 3-aryl benzo[d]imidazo[2,1-b][1,3]thiazoles is described by the reaction of phenacyl bromide with heterocyclic amine in the presence of DABCO under aqueous medium. The method is applicable for a variety of substituted phenacyl bromides as well as 2-amino-heterocycles. An aqueous reaction medium, regioselectivity, mild reaction condition, and high yield of products are the important features of this protocol.
Keywords :
Fused imidazo-heterocycles , water , 2-Aminopyridine , Dabco , regioselectivity , Phenacyl bromide
Journal title :
Tetrahedron Letters
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Link To Document :