Record number :
1882928
Title of article :
Highly diastereoselective 1,3-dipolar cycloaddition via in situ formed ketimine ylides
Author/Authors :
Cheng، نويسنده , , Yu and Liu، نويسنده , , Yanan and Ye، نويسنده , , Jia and He، نويسنده , , Long and Kang، نويسنده , , Tai-Ran and Liu، نويسنده , , Quan-Zhong، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Pages :
4
From page :
6775
To page :
6778
Abstract :
1,3-Dipolar cycloaddition of conjugated unsaturated ketimine ylides was disclosed. The reaction of glycine ester with a series of β,γ-unsaturated keto esters in the presence of catalytic amount of TFA was found to give structurally diverse and functionally enriched pyrrolidine derivatives 3 in up to 88% yield. These processes feature a hydrolysis of glycine ketimine. A preliminary enantioselective version of the transformation was also investigated.
Keywords :
3-dipolar cycloaddition , 1 , Ketimine ylides , glycine ester , ? , ?-Unsaturated keto ester
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
Serial Year :
2012
Link To Document :
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