Record number :
1879349
Title of article :
Lewis acid mediated diastereoselective synthesis of fused fluorinated spiroketal as potential biologically active compounds
Author/Authors :
Agbaje، نويسنده , , Oluropo C. and Fadeyi، نويسنده , , Olugbeminiyi O. and Okoro، نويسنده , , Cosmas O.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Pages :
4
From page :
5297
To page :
5300
Abstract :
A series of substituted dibenzalacetones prepared using standard procedures were condensed with 5-methyl, 5-phenyl, and 5-trifluoromethyl-1,3-cyclohexanediones respectively, in toluene containing BF3·OEt as the Lewis acid catalyst. The reaction was found to be highly diastereoselective (dr, 9:1). The resulting spiroketals 1a–r were formed in moderate to good yields. In addition, a synthetically and biologically useful by-product identified as chromenone 7 was observed.
Journal title :
Tetrahedron Letters
Serial Year :
2011
Link To Document :
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