Choi، نويسنده , , Hwan Geun and Son، نويسنده , , Jung Beom and Park، نويسنده , , Dong-Sik and Ham، نويسنده , , Young Jin and Hah، نويسنده , , Jung-Mi and Sim، نويسنده , , Taebo Sim، نويسنده ,
Naturally occurring L-783277 which belongs to 14-membered resorcylic acid lactones (RALs) turned out to be a potent kinase inhibitor against MEK (MAP kinase kinase). We successfully accomplished efficient and enantioselective total synthesis of L-783277 based on convergent assembly of one aromatic unit and two chiral building blocks with efficient orthogonal protection-deprotection strategy. Three key steps composed of olefin cross metathesis, addition of acetylene derivative to aldehyde, and Yamaguchi macrolactonization were subsequently employed to construct the framework of L-783277. The optical rotation value of L-783277 is for the first time presented in this Letter.