Record number :
1862644
Title of article :
Novel sesquiterpenes and norergosterol from the soft corals Nephthea erecta and Nephthea chabroli
Author/Authors :
Cheng، نويسنده , , Shi-Yie and Huang، نويسنده , , Ya-Chiang and Wen، نويسنده , , Zhi-Hong and Chiou، نويسنده , , Shu-Fen and Wang، نويسنده , , Shang-Kewi and Hsu، نويسنده , , Chi-Hsin and Dai، نويسنده , , Chang-Feng and Duh، نويسنده , , Chang-Yih، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Pages :
5
From page :
802
To page :
806
Abstract :
Chemical investigations on the acetone extract of the Formosan soft coral Nephthea erecta have afforded a new calamenene-type sesquiterpene with a mercaptan group at C-15, erectathiol (1), and a previously reported sesquiterpenoid, (+)-trans-calamenene (2). A novel sec-germacrane sesquiterpene (3), along with a novel norergosterol, chabrosterol (4), possessing a 19-norergostane skeleton, was isolated from the other soft coral Nephthea chabroli. The structures of these metabolites were elucidated through extensive spectroscopic analyses. In vitro anti-inflammatory activity of 1 and 4 (10 μM) significantly reduced the levels of the iNOS protein (58.0 ± 6.5% and 12.4 ± 2.9%) and COX-2 protein (108.7 ± 4.5% and 45.2 ± 5.4%). In addition, metabolite 1 (166 μg/disk) exhibited antimicrobial activities against a small panel of bacterial strains.
Keywords :
Calamenene-type , Nephthea erecta , Norergosterol , Nephthea chabroli , Antimicrobial activities , anti-inflammatory activity , Mercaptan , sec-Germacrane
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
Serial Year :
2009
Link To Document :
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