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Title of article :
Effects of hesperetin on the production of inflammatory mediators in IL-1β treated human synovial cells
Author/Authors :
Choi، نويسنده , , Eun Mi and Lee، نويسنده , , Young Soon، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
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Abstract :
This study was conducted to evaluate the efficacy of hesperetin in regulating interleukin-1β (IL-1β)-induced production of the matrix metalloproteinase (MMP)-3 and IL-6 in human synovial cell line, SW982. Treatment with hesperetin at 1 or 10 μM significantly (P < 0.05) inhibited IL-1β-induced MMP-3 and IL-6 production when measured by enzyme-linked immunosorbent assay (ELISA). The effects of hesperetin on the activation of mitogen-activated protein kinases (MAPKs) were also examined in SW982 cells by ELISA assay. IL-1β-induced JNK activation was inhibited by hesperetin. These results suggest that hesperetin reduces the production of MMP and IL-6 in SW982 synovial cells by inhibiting JNK.
Keywords :
Hesperetin , SW982 , matrix metalloproteinases , cytokines , Mitogen-activated protein kinases
Journal title :
Cellular Immunology
Journal title :
Cellular Immunology
Serial Year :
Link To Document :