Title of article :
Granulomatous disease in common variable immunodeficiency
Ardeniz KaragOz Ozturk، نويسنده , , ضmür and Cunningham-Rundles، نويسنده , , Charlotte، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Granulomatous disease occurs in 8–22% of patients with common variable immunodeficiency (CVID). We examined the clinical and immunologic information of all 37 of 455 (8.1%) CVID subjects with this complication. The median age at diagnosis of CVID was 26 (2–59). 14 had granulomas 1–18 years before diagnosis of CVID. In 6 detection of granulomas coincided with this diagnosis; for 17, granulomas were documented later. 54% had lung granulomas, 43% in lymph nodes and 32% in liver. 54% of the group had had autoimmune diseases, mostly immune thrombocytopenia and hemolytic anemia. 24% had had a splenectomy. Nineteen (51.3%) required steroid treatment for granulomas; other immune suppressants were used in some. Over 25 years 28.5% died (median age 37.5), but not significantly more when compared to our CVID patients without granulomas (19.8%). Those with lung granulomas had similar mortality to those with granulomas in other tissues.
TNF-Alpha , Common variable immune deficiency , Autoimmunity , Granulomatous disease , mortality , Lung disease
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