Record number :
1850891
Title of article :
First synthesis of (+)-8-methoxygoniodiol and its analogue, 8-deoxygoniodiol, using a three component strategy
Author/Authors :
Carreaux، نويسنده , , François and Favre، نويسنده , , Annaick and Carboni، نويسنده , , Bertrand and Rouaud، نويسنده , , Isabelle and Boustie، نويسنده , , Joel، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2006
Pages :
4
From page :
4545
To page :
4548
Abstract :
We have described the first total synthesis of the natural product, (+)-8-methoxygoniodiol, and its analogue, 8-deoxygoniodiol using a catalytic asymmetric hetero-Diels–Alder/allylboration sequence involving three partners. The cytotoxic activity of these final compounds and of two synthetic intermediates has been evaluated against human cancer cell lines (A375P and A375M), showing the importance of the lactone moiety.
Keywords :
Asymmetric catalysis , hetero-Diels–Alder , natural product , cytotoxicity , Allylboration reaction , 8-Deoxygoniodiol , (+)-8-Methoxygoniodiol
Journal title :
Tetrahedron Letters
Serial Year :
2006
Link To Document :
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