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Title of article :
Radiation coronary arteritis refractory to surgical and percutaneous revascularization culminating in orthotopic heart transplantation
Author/Authors :
Cheng، نويسنده , , Richard K. and Lee، نويسنده , , Michael S. and Seki، نويسنده , , Atsuko and Shemin، نويسنده , , Richard J. and Cruz، نويسنده , , Daniel and Lluri، نويسنده , , Gentian and Mitchell، نويسنده , , George D. and Yang، نويسنده , , Eric H.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
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Abstract :
AbstractBackground nʹs lymphoma (HL) comprises of 4% of malignancies diagnosed in children from birth to 14 years of age. While overall survival rates have increased, HL survivors can be at risk of late cardiovascular complications from radiotherapy. HL survivors with a history of mediastinal RT have been found to have an increased incidence of myocardial infarction, angina, congestive heart failure, and valvular disorders compared to the general population. s ear old female with a history of HL status post chemotherapy and mediastinal radiation 11 years ago became symptomatic with multivessel coronary artery disease with aggressive progression of her disease despite coronary bypass graft surgery, patch angioplasty of the left main coronary artery (LMCA) with an extracellular bioscaffold, and repeated percutaneous coronary intervention of the LMCA. She eventually underwent orthotopic heart transplant and did well postoperatively. s athological analysis of the explanted heart revealed a variety of sequelae of radiation arteritis, including thrombosis of both native vessels and arterial grafts, intimal hyperplasia and involvement of the bioscaffold in the left main coronary vasculature. The bioscaffold did not contribute significantly to the stenosis within the LMCA. sion se demonstrates an unusual indication for OHT due to severe refractory radiation induced CAD, as well the wide spectrum of the histopathologic manifestations of radiation induced arteritis.
Keywords :
coronary artery bypass graft , Heart transplantation , Coronary Artery Disease , Myocardial infarction , percutaneous transluminal angioplasty , Arteriolopathy , radiation
Journal title :
Cardiovascular Pathology
Journal title :
Cardiovascular Pathology
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Link To Document :