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Title of article :
Efficient and direct solid phase synthesis of ketomethylenimino and ketomethylenamino peptides
Author/Authors :
Bernard، نويسنده , , Elise and Vanderesse، نويسنده , , Régis، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
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Abstract :
The aim of this study is the synthesis of pseudopeptides on solid supports, in order to quickly obtain modified peptides. We report a convenient step-by-step synthesis of ketomethylenimino ψ[CO–CHN] and ketomethylenamino ψ[CO–CH2–NH] peptides. The key is the reaction between the free amino terminus of the supported peptide and a glyoxal-modified amino acid, leading to a ketomethylenimino bond, which can be reduced to a ketomethylenamino bond.
Keywords :
Solid phase peptide synthesis , Pseudopeptide , glyoxal , Ketomethylenimino , Ketomethylenamino
Journal title :
Tetrahedron Letters
Serial Year :
Link To Document :