Record number :
1843294
Title of article :
Synthesis of modified Weinreb amides: N-tert-butoxy-N-methylamides as effective acylating agents
Author/Authors :
Bernard Labeeuw، نويسنده , , Olivier and Phansavath، نويسنده , , Phannarath and Genêt، نويسنده , , Jean-Pierre، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Pages :
4
From page :
7107
To page :
7110
Abstract :
An efficient preparation of N-methyl-O-tert-butylhydroxylamine hydrochloride has been settled, which allowed the synthesis of modified Weinreb amides. Nucleophilic addition of organolithium and Grignard reagents on these N-tert-butoxy-N-methylamides afforded efficiently the corresponding ketones and reduction with DIBAL furnished the corresponding aldehydes in good yields up to 97%.
Keywords :
N-Methyl-O-tert-butylhydroxylamide , acylation , Aldehydes , ketones , Weinreb amides
Journal title :
Tetrahedron Letters
Serial Year :
2004
Link To Document :
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