Title of article :
Synthesis of modified Weinreb amides: N-tert-butoxy-N-methylamides as effective acylating agents
Bernard Labeeuw، نويسنده , , Olivier and Phansavath، نويسنده , , Phannarath and Genêt، نويسنده , , Jean-Pierre، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
An efficient preparation of N-methyl-O-tert-butylhydroxylamine hydrochloride has been settled, which allowed the synthesis of modified Weinreb amides. Nucleophilic addition of organolithium and Grignard reagents on these N-tert-butoxy-N-methylamides afforded efficiently the corresponding ketones and reduction with DIBAL furnished the corresponding aldehydes in good yields up to 97%.
N-Methyl-O-tert-butylhydroxylamide , acylation , Aldehydes , ketones , Weinreb amides
Journal title :