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Title of article :
Anticancer oral therapy: Emerging related issues
Author/Authors :
Banna، نويسنده , , Giuseppe Luigi and Collovà، نويسنده , , Elena and Gebbia، نويسنده , , Vittorio and Lipari، نويسنده , , Helga and Giuffrida، نويسنده , , Pietro and Cavallaro، نويسنده , , Sebastiano and Condorelli، نويسنده , , Rosaria and Buscarino، نويسنده , , Calogero and Tralongo، نويسنده , , Paolo and Ferraù، نويسنده , , Francesco، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
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Abstract :
The use of oral anticancer drugs has shown a steady increase. Most patients prefer anticancer oral therapy to intravenous treatment primarily for the convenience of a home-based therapy, although they require that the efficacy of oral therapy must be equivalent and toxicity not superior than those expected with the intravenous treatment. A better patient compliance, drug tolerability, convenience and possible better efficacy for oral therapy as compared to intravenous emerge as the major reasons to use oral anticancer agents among oncologists. Inter- and intra-individual pharmacokinetic variations in the bioavailability of oral anticancer drugs may be more relevant than for intravenous agents. Compliance is particularly important for oral therapy because it determines the dose-intensity of the treatment and ultimately treatment efficacy and toxicity. Patient stands as the most important determinant of compliance. Possible measures for an active and safe administration of oral therapy include a careful preliminary medical evaluation and selection of patients based on possible barriers to an adequate compliance, pharmacologic issues, patient-focused education, an improvement of the accessibility to healthcare service, as well as the development of home-care nursing symptom-focused interventions. Current evidences show similar quality of life profile between oral and intravenous treatments, although anticancer oral therapy seems to be more convenient in terms of administration and reduced time lost for work or other activities. Regarding cost-effectiveness, current evidences are in favor of oral therapy, mainly due to reduced need of visits and/or day in hospital for the administration of the drug and/or the management of adverse events.
Keywords :
Drug–drug interaction , Oral therapy , cancer , Compliance , adherence , persistence , Pharmacogenomics , Pharmacokinetics , Quality of life , Cost
Journal title :
Cancer Treatment Reviews
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Link To Document :