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Title of article :
Assessment of metabolic changes in the striatum of a MPTP-intoxicated canine model: in vivo 1H-MRS study of an animal model for Parkinsonʹs disease
Author/Authors :
Choi، نويسنده , , Chi-Bong and Kim، نويسنده , , Sang-Young and Lee، نويسنده , , Sung-Ho and Jahng، نويسنده , , Geon-Ho and Kim، نويسنده , , Hwi-Yool and Choe، نويسنده , , Bo-Young and Ryu، نويسنده , , Kyung-Nam and Yang، نويسنده , , Dal-Mo and Yim، نويسنده , , Sung-Vin and Choi، نويسنده , , Woo-Suk، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
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Abstract :
Parkinsonʹs disease (PD) is a neurodegenerative disorder characterized by the progressive loss of the dopaminergic neurons in the substantia nigra pars compacta, which projects to the striatum. We induced a selective loss of nigrostriatal dopamine neurons, by infusing the mitochondrial complex 1 inhibitor 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine (MPTP) into adult beagle dogs (N=5). Single voxel 1H water suppressed magnetic resonance spectroscopy (1H-MRS) at 3 T was used to assess the metabolic changes in the striatum of canine before and after MPTP intoxication. The metabolite spectra obtained from the striatum (voxel size: 2 cm3) showed a lower N-acetyl aspartate to total creatine (creatine+phosphocreatine) ratio after MPTP intoxication. There were no significant differences in other metabolite ratios such as glutamate+glutamine, choline-containing compounds (glycerophosphocholine+phophorylcholine and myo-inositol). Our findings indicated that 1H-MRS is a sensitive, noninvasive measure of neural toxicity and biochemical alterations of the striatum in a canine model of PD, and further studies are needed to confirm brain metabolic changes in association with progression of MPTP-intoxication.
Keywords :
Parkinsonיs disease , 1-methyl 4-phenyl 1 , 2 , 3 , 1H-MRS , 6-tetrahydropyridine , Canine model , striatum
Journal title :
Magnetic Resonance Imaging
Journal title :
Magnetic Resonance Imaging
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