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Title of article :
Id1 promotes lung cancer cell proliferation and tumor growth through Akt-related pathway
Author/Authors :
Cheng، نويسنده , , Yu-Jen and Tsai، نويسنده , , Jen-Wei and Hsieh، نويسنده , , Kun-Chou and Yang، نويسنده , , Yu-Chi and Chen، نويسنده , , Yun-Ju and Huang، نويسنده , , Ming-Shyang and Yuan، نويسنده , , Shyng-Shiou F.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
Pages :
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Abstract :
Overexpression of Id family proteins inhibits cell differentiation and enhances cell proliferation and invasiveness. Although Id1 is the Id family member mostly linked to tumorigenesis, its role in lung cancer is unclear. An elevated Id1 expression was observed in lung cancer cell lines as well as lung cancer tissues. Id1 overexpression increased cell proliferation while Id1 knockdown decreased cell proliferation, mostly through Akt-related pathway. Nude mice study further confirmed an increased tumor growth in Id1-overexpressing cells and a decreased tumor growth in Id1-knockdowned cells. In conclusion, inactivation of Id1 may provide a novel strategy for treatment of lung cancer patients.
Keywords :
lung cancer , Id1 protein , tumorigenesis
Journal title :
Cancer Letters
Journal title :
Cancer Letters
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Link To Document :