Cho، نويسنده , , Young-Seok and Yoon، نويسنده , , Tae-Jong and Jang، نويسنده , , Eue-Soon and Soo Hong، نويسنده , , Kwan and Young Lee، نويسنده , , Shin and Ran Kim، نويسنده , , Ok and Park، نويسنده , , Cheongsoo and Kim، نويسنده , , Yong-Jin and Yi، نويسنده , , Gyu-Chul and Chang، نويسنده , , Kiyuk Chang، نويسنده ,
Magneto-fluorescent silica nanoparticles were conjugated with cetuximab for the targeting and imaging of colon cancer. In this study, cetuximab-conjugated magneto-fluorescent nanoparticles (MFSN-Ctx) could specifically target colon cancer cells that expressed EGFR on their cell membranes, and specific fluorescence was detected. MFSN-Ctx produced significant MRI signal changes in a human colon cancer xenograft mouse model. Intravenous injection of MFSN-Ctx resulted in faster uptake as compared to intraperitoneal injection, indicating that MFSN-Ctx had different kinetic properties in tumors based on the method of injection. The local concentration of MFSN-Ctx in a tumor was amplified by the use of an external magnetic field. These results demonstrate the potential application of MFSN-Ctx for the detection of EGFR-expressing colon cancer using in vivo imaging approaches.
Nanoparticles , Colon cancer , molecular imaging , cetuximab