Record number :
1817402
Title of article :
DARRIERS’S DISEASE – AN UNCOMMON SKIN CONDITION IN BELLARY REGION.
Author/Authors :
Bharath، Dr. C. نويسنده Department of Pathology, Medical College (VIMS), BELLARY – 583 104. Karnataka. , , Pompapathi، S نويسنده Department of Skin & STD, Medical College (VIMS), BELLARY – 583 1204. Karnataka. INDIA. ,
Issue Information :
فصلنامه با شماره پیاپی سال 2013
Pages :
2
From page :
24
To page :
25
Abstract :
Background : Darriers disease is a genetic disorder, either transmitted as autosomal dominant disorder or as a mutation, producing abnormalities in keratinization, which is characterized by persistent eruption of hyperkeratotic papules. It usually has its onset during childhood and affects both sexes equally. The prevalence is 50,000 to 1,00,000 population. Objectives: As this is an uncommon genetic lesion of dyskeratosis from Bellary region, this case report is presented. Method: A skin biopsy was sent to department of pathology, Medical College (VIMS), Bellary. The specimen was grey brown bits, processed in histokinette, by sequential changes in alcohol, xylene and embedded in paraffin bath, blocks were made, serial sections were taken at 5u thickness and H & E stain was done. Results: Histologically, the epithelium showed acanthosis, hyperkeratosis, with foci of suprabasal clefts, along with corps ronds and grains of keratin and diagnosed as Darriers disease. Conclusion: As this skin lesion is uncommon with genetic autosomal dominant disorder, producing abnormalities in keratinisation, it has to be differentiated from early lesions and the other keratotic lesions, where biopsy plays a vital role for accurate diagnosis and limiting the disease and avoiding further complications.
Journal title :
International Journal of Analytical, Pharmaceutical and Biomedical Sciences
Serial Year :
2013
Link To Document :
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