Choi، نويسنده , , Bo-Hwa and Kim، نويسنده , , Wanil and Wang، نويسنده , , Qiuxia Chelsia and Kim، نويسنده , , Dong-Chan and Tan، نويسنده , , Swee Ngin and Yong، نويسنده , , Jean Wan Hong and Kim، نويسنده , , Kyong-Tai and Yoon، نويسنده , , Ho Sup، نويسنده ,
Here, we demonstrate that kinetin riboside (KR), a cytokinin analog, induces apoptosis in HeLa and mouse melanoma B16F-10 cells. KR disrupted the mitochondrial membrane potential and induced the release of cytochrome c and activation of caspase-3. Bad were upregulated while Bcl-2 was down-regulated under KR exposure. A tumor growth in mice was dramatically suppressed by KR. In contrast, human skin fibroblast CCL-116 and bovine primary fibroblast cells show resistances to KR and no significant changes in Bad, Bcl-XL, and cleaved PARP were observed. Our data suggest that KR selectively induces apoptosis in cancer cells through the classical mitochondria dependent apoptosis pathway.
Kinetin riboside , caspase-3 , bcl-2 , apoptosis , cancer