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Title of article :
Amphiregulin: A new growth factor in hepatocarcinogenesis
Author/Authors :
Carmen Berasain، نويسنده , , C. and Castillo، نويسنده , , J. and Perugorrيa، نويسنده , , M.J. and Prieto، نويسنده , , J. C. Avila Vilchis، نويسنده , , M.A.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
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Abstract :
Amphiregulin (AR) is a member of the epidermal growth factor family and a ligand of the epidermal growth factor receptor (EGFR). As other ligands of the EGFR, AR is synthesized as a precursor that is shed from the plasma membrane by metalloproteases. Hyperactive autocrine loops involving AR production have been described in a variety of tumors, and this growth factor is thought to play a non-redundant role in cancer development. AR expression is not detected in the normal liver, however it is readily induced during acute liver injury and behaves as a potent pro-regenerative and survival factor. Increased AR expression is also detected in human chronic liver injury (liver cirrhosis), which is considered a pre-neoplastic condition. Recent evidences suggest that AR can play a unique role in liver tumorigenesis and in the maintenance of the neoplastic phenotype of hepatocarcinoma cells. In this review, we summarize some aspects of AR patho-biology and the rationale behind its definition as a novel target in hepatocarcinoma therapy.
Keywords :
Amphiregulin , Proliferation , Liver injury , Cirrhosis , Carcinogenesis , Hepatocarcinoma
Journal title :
Cancer Letters
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