Record number :
1805680
Title of article :
Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase
Author/Authors :
Ahsan، نويسنده , , Habibul and Chen، نويسنده , , Yu and Kibriya، نويسنده , , Muhammad G and Islam، نويسنده , , Mohammad N and Slavkovich، نويسنده , , Vesna N and Graziano، نويسنده , , Joseph H and Santella، نويسنده , , Regina M، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Pages :
9
From page :
57
To page :
65
Abstract :
Chronic exposure to inorganic arsenic is known to cause non-melanocytic skin and internal cancers in humans. We examined whether genetic susceptibility, as determined by single nucleotide polymorphisms −463 G→A and −262 C→T in the oxidative stress genes myeloperoxidase (MPO) and catalase (CAT), respectively, are associated with the risk of arsenic-induced hyperkeratotic skin lesions—precursors of skin cancer—in a case–control study in Bangladesh. Carriers of the susceptible MPO and CAT genotypes were at elevated risk (OR 2.1 and 95% CI 0.7–6.2 for MPO; OR 1.9 and 95% CI 0.8–4.7 for CAT) of hyperkeratosis after adjustment for arsenic exposure and other covariates. Subjects carrying the high-risk MPO genotype and with high arsenic exposure were at almost six times (OR 5.8; 95% CI 1.1–30.1) elevated risk of developing hyperkeratosis as compared to those carrying the low-risk genotype and with low arsenic exposure. Similarly, highly exposed subjects carrying the high-risk CAT genotype were at more than four times (OR 4.6; 95% CI 1.4–15.6) elevated risk of developing hyperkeratosis as compared to those carrying the low-risk genotype and with low arsenic exposure. Our findings, although based on small numbers, suggest that the oxidative stress genes MPO and CAT may influence the risk of arsenic-induced premalignant hyperkeratotic skin lesions.
Keywords :
Arsenic , MPO , Oxidative stress genes , Gene–environmental interaction , Genetic susceptibility , CAT
Journal title :
Cancer Letters
Serial Year :
2003
Link To Document :
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