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Title of article :
Synthetic liver X receptor agonist T0901317 attenuates high glucose-induced oxidative stress, mitochondrial damage and apoptosis in cardiomyocytes
Author/Authors :
Cheng، نويسنده , , Yongxia and Feng، نويسنده , , Yukuan and Zhu، نويسنده , , Min and Yan، نويسنده , , Bin and Fu، نويسنده , , Songbin and Guo، نويسنده , , Jin and Hu، نويسنده , , Jing and Song، نويسنده , , Xiandong and Guo، نويسنده , , Sufen and Liu، نويسنده , , Guibo، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
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Abstract :
The aim of the present study was to investigate the protective effects of T0901317 (T0), a potent agonist of liver X receptors (LXRs), on high glucose-induced oxidative stress and apoptosis in H9c2 cardiac cells. Exposure of H9c2 cells to high glucose alone, not only caused a significant increase in apoptosis and reactive oxygen species (ROS) generation, but also led to a decrease in mitochondrial membrane potential (ΔΨm), release of cytochrome c, decrease in Bcl-2, increase in Bax expression and the activation of caspase-3, caspase-9, poly (ADP-ribose) polymerase (PARP) and nuclear factor (NF)-κB. However, pretreatment with T0 effectively decreased apoptosis, reduced the levels of ROS, abrogated ΔΨm, inhibited cytochrome c release and NF-κB activation, increased Bcl-2 and decreased Bax expression. In conclusion, our data suggest that T0 exerts protective effects against high glucose-induced apoptosis in H9C2 cardiac muscle cells via inhibition of ROS production, mitochondrial death and NF-κB activation.
Keywords :
cardiomyocytes , Mitochondrial damage , High glucose , Liver X receptor agonist T0901317 , apoptosis
Journal title :
Acta Histochemica
Journal title :
Acta Histochemica
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