Title of article :
Healthy Lifestyle and Decreasing Risk of Heart Failure in Women: The Womenʹs Health Initiative Observational Study
Agha، نويسنده , , Golareh and Loucks، نويسنده , , Eric B. and Tinker، نويسنده , , Lesley F. and Waring، نويسنده , , Molly E. and Michaud، نويسنده , , Dominique S. and Foraker، نويسنده , , Randi E. and Li، نويسنده , , Wenjun and Martin، نويسنده , , Lisa W. and Greenland، نويسنده , , Philip and Manson، نويسنده , , JoAnn E. and Eaton، نويسنده , , Charles B.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
pact of a healthy lifestyle on risk of heart failure (HF) is not well known.
jectives of this study were to evaluate the effect of a combination of lifestyle factors on incident HF and to further investigate whether weighting each lifestyle factor has additional impact.
ipants were 84,537 post-menopausal women from the WHI (Women’s Health Initiative) observational study, free of self-reported HF at baseline. A healthy lifestyle score (HL score) was created wherein women received 1 point for each healthy criterion met: high-scoring Alternative Healthy Eating Index, physically active, healthy body mass index, and currently not smoking. A weighted score (wHL score) was also created in which each lifestyle factor was weighted according to its independent magnitude of effect on HF. The incidence of hospitalized HF was determined by trained adjudicators using standardized methodology.
were 1,826 HF cases over a mean follow-up of 11 years. HL score was strongly associated with risk of HF (multivariable-adjusted hazard ratio [HR] [95% confidence interval (CI)] 0.49 [95% CI: 0.38 to 0.62], 0.36 [95% CI: 0.28 to 0.46], 0.24 [95% CI: 0.19 to 0.31], and 0.23 [95% CI: 0.17 to 0.30] for HL score of 1, 2, 3, and 4 vs. 0, respectively). The HL score and wHL score were similarly associated with HF risk (HR: 0.46 [95% CI: 0.41 to 0.52] for HL score; HR: 0.48 [95% CI: 0.42 to 0.55] for wHL score, comparing the highest tertile to the lowest). The HL score was also strongly associated with HF risk among women without antecedent coronary heart disease, diabetes, or hypertension.
reasingly healthy lifestyle was associated with decreasing HF risk among post-menopausal women, even in the absence of antecedent coronary heart disease, hypertension, and diabetes. Weighting the lifestyle factors had minimal impact.
Cardiovascular diseases , Lifestyle , heart failure , Primary Prevention , risk factors
Journal title :
JACC (Journal of the American College of Cardiology)