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Title of article :
Pentraxin 3 Is a New Inflammatory Marker Correlated With Left Ventricular Diastolic Dysfunction and Heart Failure With Normal Ejection Fraction
Author/Authors :
Matsubara، نويسنده , , Junichi and Sugiyama، نويسنده , , Seigo and Nozaki، نويسنده , , Toshimitsu and Sugamura، نويسنده , , Koichi and Konishi، نويسنده , , Masaaki and Ohba، نويسنده , , Keisuke and Matsuzawa، نويسنده , , Yasushi and Akiyama، نويسنده , , Eiichi and Yamamoto، نويسنده , , Eiichiro and Sakamoto، نويسنده , , Kenji and Nagayoshi، نويسنده , , Yasuhiro and Kaikita، نويسنده , , Koichi and Sumida، نويسنده , , Hitoshi and Kim-Mitsuyama، نويسنده , , Shokei and Ogawa، نويسنده , , Hisao، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
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Abstract :
Objectives tudy investigated the clinical significance of plasma pentraxin 3 (PTX3) levels in patients with heart failure with normal ejection fraction (HFNEF) and whether PTX3 is produced from coronary circulation. ound xin 3 is a novel inflammatory marker and a member of pentraxin superfamily including C-reactive protein (CRP). The relationship between inflammatory markers and HFNEF remains unclear. s sured peripheral blood levels of PTX3, high-sensitivity CRP, tumor necrosis factor-alpha, and interleukin-6 in 323 patients comprising 82 HFNEF, 70 heart failure (HF) with reduced EF, and 171 non-HF patients. Levels of PTX3 were also measured at the aortic root and the coronary sinus in 75 patients. s vels of PTX3, tumor necrosis factor-alpha, and interleukin-6, but not high-sensitivity CRP, were significantly higher in HFNEF patients than in non-HF patients. Multivariate logistic regression analysis identified only high levels of PTX3 as the independent inflammatory marker correlated with the presence of HFNEF in patients with normal left ventricular (LV) EF (odds ratio [OR]: 1.49, 95% confidence interval [CI]: 1.11 to 1.98, p < 0.01) and with the presence of left ventricular diastolic dysfunction (LVDD) in non-HF patients (OR: 1.23, 95% CI: 1.02 to 1.50, p < 0.05). Levels of PTX3 at the coronary sinus were significantly higher than at the aortic root in HFNEF patients (p < 0.05) and in non-HF patients with LVDD (p < 0.01), but not different in non-HF patients without LVDD (p = 0.33). sions xin 3 is significantly elevated in HFNEF patients and produced in the coronary circulation in patients with LVDD. Pentraxin 3, but not high-sensitivity CRP, is an independent inflammatory marker correlated with the presence of LVDD and HFNEF. (The Clinical Significance of Plasma Pentraxin 3 levels for Patients with Diastolic Heart Failure; UMIN000002170)
Keywords :
coronary circulation , left ventricular diastolic dysfunction , Pentraxin 3 , Heart failure with normal ejection fraction
Journal title :
JACC (Journal of the American College of Cardiology)
Journal title :
JACC (Journal of the American College of Cardiology)
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