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Title of article :
Eptifibatide Is Noninferior to Abciximab in Primary Percutaneous Coronary Intervention: Results From the SCAAR (Swedish Coronary Angiography and Angioplasty Registry)
Author/Authors :
إkerblom، نويسنده , , Axel and James، نويسنده , , Stefan K. and Koutouzis، نويسنده , , Michail and Lagerqvist، نويسنده , , Bo and Stenestrand، نويسنده , , Ulf and Svennblad، نويسنده , , Bodil and Oldgren، نويسنده , , Jonas، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Pages :
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Abstract :
Objectives m of this study was to test the noninferiority of eptifibatide relative to abciximab in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). ound rotein IIb/IIIa inhibitors are recommended by international guidelines in patients with acute coronary syndromes undergoing PCI. Abciximab is recommended with a higher level of evidence than eptifibatide in patients with STEMI. No large, prospective, randomized trial comparing abciximab and eptifibatide has been published. s = 11,479) STEMI patients in Sweden who underwent primary PCI and received either eptifibatide or abciximab from 2004 to 2007 were derived from the SCAAR (Swedish Coronary Angiography and Angioplasty Registry). The primary end point was death or myocardial infarction (MI) during 1-year follow-up, with adjustment for baseline differences with a multivariate logistic regression analysis including propensity score. The pre-specified noninferiority margin was set to 1.29. s mbined end point occurred in 353 of 2,355 patients (15.0%) treated with eptifibatide and in 1,432 of 9,124 patients (15.7%) treated with abciximab. The unadjusted odds ratio (OR) for eptifibatide versus abciximab was 0.95 (95% confidence interval [CI]: 0.84 to 1.08). Multivariate adjustment (n = 11,317) confirmed noninferiority, with an OR of 0.94 (95% CI: 0.82 to 1.09). The adjusted secondary end points of death and MI separately also showed noninferiority, with ORs of 0.99 (95% CI: 0.82 to 1.19) and 0.88 (95% CI: 0.73 to 1.05), respectively. sions arge registry study suggests that eptifibatide is noninferior to abciximab in patients with STEMI undergoing primary PCI with respect to death or MI during 1 year, thereby supporting the use of either drug in clinical practice.
Keywords :
ST-segment elevation myocardial infarction , Abciximab , Eptifibatide , Myocardial infarction , Death
Journal title :
JACC (Journal of the American College of Cardiology)
Journal title :
JACC (Journal of the American College of Cardiology)
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