Record number :
1747077
Title of article :
Impact of Stent Overlap on Angiographic and Long-Term Clinical Outcome in Patients Undergoing Drug-Eluting Stent Implantation
Author/Authors :
Rنber، نويسنده , , Lorenz and Jüni، نويسنده , , Peter and Lِffel، نويسنده , , Lukas and Wandel، نويسنده , , Simon and Cook، نويسنده , , Stéphane and Wenaweser، نويسنده , , Peter and Togni، نويسنده , , Mario and Vogel، نويسنده , , Rolf and Seiler، نويسنده , , Christian and Eberli، نويسنده , , Franz and Lüscher، نويسنده , , Thomas and Meier، نويسنده , , Bernhard and Windecker، نويسنده , , Stephan، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Pages :
11
From page :
1178
To page :
1188
Abstract :
Objectives pared the angiographic and long-term clinical outcomes of patients with and without overlap of drug-eluting stents (DES). ound erlap has been associated with delayed healing and increased inflammation in experimental studies, but its impact on clinical outcome is not well established. s lyzed the angiographic and clinical outcomes of 1,012 patients treated with DES in the SIRTAX (Sirolimus-Eluting Versus Paclitaxel-Eluting Stents for Coronary Revascularization) trial according to the presence or absence of stent overlap and the number of stents per vessel: 134 (13.2%) patients with multiple DES in a vessel with overlap, 199 (19.7%) patients with multiple DES in a vessel without overlap, and 679 (67.1%) patients with 1 DES per vessel. s raphic follow-up at 8 months showed an increased late loss in DES overlap patients (0.33 ± 0.61 mm) compared with the other groups (0.18 ± 0.43 mm and 0.15 ± 0.38 mm, p < 0.01). The smallest minimal lumen diameter was located at the zone of stent overlap in 17 (68%) of 25 patients with stent overlap who underwent target lesion revascularization. Major adverse cardiac events were more common in patients with DES overlap (34 events, 25.4%) than in the other groups (42 events, 21.1% and 95 events, 14.0%) at 3 years (p < 0.01). Both the risk of target lesion revascularization (20.2% vs. 16.1% vs. 9.7%, p < 0.01) and the composite of death or myocardial infarction (17.2% vs. 14.1% vs. 9.1%, p = 0.01) were increased in patients with DES overlap compared with the other groups. sions erlap occurs in >10% of patients undergoing percutaneous coronary intervention in routine clinical practice and is associated with impaired angiographic and long-term clinical outcome, including death or myocardial infarction. (Sirolimus-Eluting Versus Paclitaxel-Eluting Stents for Coronary Revascularization; NCT00297661).
Keywords :
Coronary Artery Disease , Drugs , Overlap , restenosis , stents
Journal title :
JACC (Journal of the American College of Cardiology)
Link To Document :