Record number :
1676809
Title of article :
Determination of gemfibrozil in pharmaceutical and urine samples by square-wave adsorptive stripping voltammetry using a glassy carbon electrode modified with multi-walled carbon nanotubes within a dihexadecyl hydrogen phosphate film
Author/Authors :
Ardila، نويسنده , , Jorge Armando and Oliveira، نويسنده , , Geiser Gabriel and Medeiros، نويسنده , , Roberta Antigo and Fatibello-Filho، نويسنده , , Orlando، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Pages :
6
From page :
32
To page :
37
Abstract :
Glassy carbon electrode modified with functionalized multi-walled carbon nanotubes within a dihexadecyl hydrogen phosphate film was used to develop a sensitive and simple square-wave adsorptive stripping voltammetric (SWAdSV) method for the determination of gemfibrozil. The cyclic voltammograms obtained showed one irreversible anodic peak for gemfibrozil at a potential of 1.3 V using a 0.1 mol L−1 phosphate buffer solution (pH 2.0). The cyclic voltammetric responses were studied with regard to scan rate, and the number of electrons transferred during the oxidation process was calculated. A calibration curve for gemfibrozil in the concentration range from 75 to 1000 nmol L−1 with a detection limit of 53 nmol L−1 were obtained. The proposed SWAdSV method was successfully applied to determine gemfibrozil in pharmaceutical and urine samples with good accuracy and precision.
Keywords :
Modified electrode , Square-wave adsorptive stripping voltammetry (SWAdSV) , Gemfibrozil , Multi-walled carbon Nanotubes , Dihexadecyl hydrogen phosphate
Journal title :
Journal of Electroanalytical Chemistry
Serial Year :
2013
Link To Document :
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