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Title of article :
Square-wave voltammetric determination of bezafibrate in pharmaceutical formulations using a cathodically pretreated boron-doped diamond electrode
Author/Authors :
Ardila، نويسنده , , Jorge Armando and Sartori، نويسنده , , Elen Romمo and Rocha-Filho، نويسنده , , Romeu C. and Fatibello-Filho، نويسنده , , Orlando، نويسنده ,
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ماهنامه با شماره پیاپی سال 2013
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Abstract :
The determination of bezafibrate (BZF) using square-wave voltammetry (SWV) and a cathodically pretreated boron-doped diamond electrode is proposed. Cyclic voltammetry results showed one irreversible oxidation peak for BZF at 1.20 V (vs. Ag/AgCl (3.0 mol L−1 KCl)) in a 0.04 mol L−1 Britton–Robinson (BR) buffer solution (pH 2.0). Under optimized SWV conditions, a linear analytical curve is obtained for the BZF concentration range 0.10–9.1 μmol L−1 in the BR buffer solution (pH 2.0), with a detection limit of 0.098 μmol L−1. The obtained recoveries range from 93.4 to 108%. The proposed novel method was successfully applied in the determination of the BZF content in several pharmaceutical formulations (tablets) and the results are in close agreement (at a 95% confidence level) with those obtained using a comparative spectrophotometric method.
Keywords :
Bezafibrate electroanalytical determination , BDD electrode , Cathodic pretreatment , Square-wave voltammetry
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