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Title of article :
A novel and efficient macrolactonization of ω-hydroxycarboxylic acids using 2-methyl-6-nitrobenzoic anhydride (MNBA)
Author/Authors :
Shiina، نويسنده , , Isamu and Kubota، نويسنده , , Mari and Ibuka، نويسنده , , Ryoutarou، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Pages :
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Abstract :
A variety of lactones were prepared in high yields at room temperature from the corresponding ω-hydroxycarboxylic acids using 2-methyl-6-nitrobenzoic anhydride in the presence of 4-(dimethylamino)pyridine. A similar reaction also occurs with triethylamine when using a catalytic amount of 4-(dimethylamino)pyridine 1-oxide as an effective promoter for the intramolecular condensation reaction. These methods were successfully applied to the synthesis of erythro-aleuritic acid lactone and the efficiency of the cyclizations is compared to those of other reported mixed anhydride methods.
Journal title :
Tetrahedron Letters
Link To Document :