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Title of article :
Synthesis of a cyclic pseudo 310 helical structure from a β-amino acid-l-proline derived tripeptide via a ring closing metathesis reaction
Author/Authors :
Banerji، نويسنده , , Biswadip and Mallesham، نويسنده , , B and Kiran Kumar، نويسنده , , S and Kunwar، نويسنده , , A.C and Iqbal، نويسنده , , Javed، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
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Abstract :
The combination of homo-phenylglycine (Hpg) and proline leads to the formation of a β-turn mimic, which can be transformed into a cyclic peptide using a ring closing metathesis reaction. The presence of the pentenoyl and allyl groups at the terminus of the peptide leads to the concomitant formation of a linker surrogate fourth amino acid (6-amino-4-hexenoic acid; Aha) during the cyclization. The cyclic peptide is unique in having a pseudo 310 helical structure.
Journal title :
Tetrahedron Letters
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Link To Document :