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Title of article :
Nanoporous niobium oxide for label-free detection of DNA hybridization events
Author/Authors :
Choi، نويسنده , , Jinsub and Lim، نويسنده , , Jae Hoon and Rho، نويسنده , , Sangchul and Jahng، نويسنده , , Deokjin and Lee، نويسنده , , Jaeyoung and Kim، نويسنده , , Kyung Ja، نويسنده ,
Issue Information :
ماهنامه با شماره پیاپی سال 2008
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Abstract :
We found that DNA probes can be immobilized on anodically prepared porous niobium oxide without a chemical modification of both the DNA probes and the substrate. By using the porous niobium oxide with a positive surface charge, DNA hybridization events are detected on the basis of the blue-shift of a maximum absorption peak in UV–vis-NIR spectroscopy. The blue-shift is ascribed to the change of surface charge upon single- or double-stranded DNA. The method does not require a label and shows high sensitivity with the detection limit of the concentration of 1 nM.
Keywords :
Porous oxide , Surface charge , Biosensor , niobium oxide , Anodization
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