Record number :
Title of article :
Synthetic studies on morphine-based analgesics: an approach to angular substitution in 4a-aryldecahydroisoquinolines via dienolate chemistry
Author/Authors :
Ong، نويسنده , , Quyen and Hameyer، نويسنده , , Helge and Handa، نويسنده , , Sheetal and Jones، نويسنده , , Keith، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Pages :
From page :
To page :
Abstract :
The reaction of the dienolate generated from 9 using lithium hexamethyldisilazide with a range of alkyl halides has been explored and the regioselectivity and stereochemistry of the adducts determined. Reaction of the dienolate with an oxaziridine gave hydroxylation at the C-8a position as found in some potent morphine-like analgesics.
Journal title :
Tetrahedron Letters
Link To Document :