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Title of article :
Immuno-arrays for multianalyte analysis of chlorotriazines
Author/Authors :
Bhand، نويسنده , , Sunil and Surugiu، نويسنده , , Ioana and Dzgoev، نويسنده , , Anatoly and Ramanathan، نويسنده , , Kumaran and Sundaram، نويسنده , , P.V. and Danielsson، نويسنده , , Bengt، نويسنده ,
Issue Information :
ماهنامه با شماره پیاپی سال 2005
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Abstract :
In this paper, a novel strategy for multicomponent analysis of two classes of pesticides such as triazines (atrazine and simazine) and phenoxyalkanoic acids (2,4-dichlorophenoxy acetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), 4-chlorophenoxyacetic acid (CPOAc), phenoxyacetic acid (POAc)) employing immuno-arrays is demonstrated. The approach is based on cross-reactive arrays of specific antibody pairs coupled to chemometric pattern recognition. The monoclonal antibody pairs employed in this work (atrazine–simazine and 2,4-D) are specific towards a set of analytes and preclude a particular set of others present in the sample matrix. Antibody pairs of atrazine, simazine, and 2,4-D are used to discriminate and quantify analyte of interest. Atrazine was quantified in presence of trace concentration of simazine and that of 2,4-D. The combinatorial cross-reactivity of antibody pairs towards simazine, atrazine and 2,4-D is used to distinguish among different classes of analytes and their influence on the signal suppression in immuno-techniques. These sensors exclude recognition by carbamates such as carbaryl and carbofuran.
Keywords :
Discriminative detection , Phenoxyalkanoic acids , Immunosensor , triazines , Cross-reactive arrays , Multicomponent analysis
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