Record number :
1646254
Title of article :
Design and synthesis of aryl/hetarylmethyl phosphonate-UMP derivatives as potential glucosyltransferase inhibitors
Author/Authors :
Bhattacharya، نويسنده , , Asish K and Stolz، نويسنده , , Florian and Schmidt، نويسنده , , Richard R، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Pages :
3
From page :
5393
To page :
5395
Abstract :
A novel class of glucosyltransferase inhibitors has been designed and synthesised. The designed inhibitors 1–4 provide conformational mimicry of the transition-state in glucosyltransfer reactions. The key synthetic steps involve a Michaelis–Arbuzov reaction followed by coupling with uridine-5′-morpholidophosphate as activated UMP derivative.
Keywords :
transition-state , glycosyltransferases , Inhibitors , Synthesis
Journal title :
Tetrahedron Letters
Serial Year :
2001
Link To Document :
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