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Title of article :
A proline-catalyzed asymmetric Robinson annulation reaction
Author/Authors :
Bui، نويسنده , , Tommy and Barbas III، نويسنده , , Carlos F، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Pages :
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Abstract :
A single-step enantioselective synthesis of the Wieland–Miescher ketone (5) is presented. We show that l-proline as well as a number of other chiral amines can act as catalysts of both steps of the Robinson annulation reaction. Other chiral amines are identified as catalysts of Michael and aldol addition reactions.
Journal title :
Tetrahedron Letters
Link To Document :