Record number :
1638264
Title of article :
Enantiospecific synthesis of (−)-3-iso-19,20-dehydro-β-yohimbine from secologanin: a route to normal and pseudo stereoisomers of yohimbine
Author/Authors :
Brown، نويسنده , , Richard T and Pratt، نويسنده , , Simon B and Richards، نويسنده , , Paul، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Pages :
4
From page :
5627
To page :
5630
Abstract :
Hydrolysis of secologanin ethylene acetal at pH 7 resulted in stereoselective aldol cyclisation to a cyclohexene aldehyde, which, on reductive amination and cyclisation with tryptamine afforded (−)-3-iso-19,20-dehydro-β-yohimbine, converted into various normal and pseudo isomers of yohimbine.
Keywords :
aldol , Alkaloids , biomimetic , indole , terpene , stereoselection
Journal title :
Tetrahedron Letters
Link To Document :