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Title of article :
Thermally cleavable safety-catch linkers for solid phase chemistry
Author/Authors :
Russell، نويسنده , , Helen E and Luke، نويسنده , , Richard W.A and Bradley، نويسنده , , Mark، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Pages :
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Abstract :
Safety-catch linkers based on the sulfoxide/selenoxide syn elimination have been developed. Clean and efficient oxidation of the sulfide to the sulfoxide was achieved with the homogeneous oxidising system comprising of hexafluoroisopropanol (HFIP) and hydrogen peroxide. Elimination of the sulfoxide was only possible with the most activated of substrates, while the selenoxide underwent cleavage under much milder conditions.
Journal title :
Tetrahedron Letters
Link To Document :