Record number :
1638073
Title of article :
A practical conversion of natural physostigmine into the potent butyrylcholinesterase inhibitor N1,N8-bisnorcymserine
Author/Authors :
Zhu، نويسنده , , Xiaoxiang and Greig، نويسنده , , Nigel H and Holloway، نويسنده , , Harold W and Whittaker، نويسنده , , Noel F and Brossi، نويسنده , , Arnold and Yu، نويسنده , , Qian-sheng، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Pages :
4
From page :
4861
To page :
4864
Abstract :
A rapid novel synthetic route to the potent reversible butyrylcholinesterase inhibitor (−)-N1,N8-bisnorcymserine (1) is reported from physostigmine (2) in a 20% total yield. Details on the formation of the imino-quinone 6 obtained in the oxidation of N1-benzylnoresermethole (4) and its conversion into N1-bisnoreseroline (7) are given. As expected, the product of this synthesis, (1), had identical biological activity to the same agent produced by total synthesis.
Keywords :
Anticholinesterase , N1 , N8-bisnorcymserine , Butyrylcholinesterase , Alzheimer’s disease therapeutic , physostigmine
Journal title :
Tetrahedron Letters
Link To Document :