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Title of article :
Geminal hydroxy phosphonate derivatives of nucleosides: A novel class of nucleoside 5′-monophosphate analogues
Author/Authors :
KRALIKOVA، K. نويسنده , , ??rka and Bud????nsk?، نويسنده , , Milo? and Masoj??dkov?، نويسنده , , Milena and Rosenberg، نويسنده , , Ivan، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Pages :
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Abstract :
A novel type of phosphonate-based, isopolar, nonisosteric 5′-nucleotide analogue, the nucleoside 5′-hydroxy phosphonates, was prepared by Abramov nucleophilic addition of various phosphorous acid esters to nucleoside 5′-aldehydes. The newly formed compounds are distinguished by chirality of the 5′-carbon atom. The configuration of the 5′-epimers was assigned from NMR spectra.
Journal title :
Tetrahedron Letters
Link To Document :