Title of article :
Studies toward the total synthesis of Sch 202596, an antagonist of the galanin receptor subtype GalR1: synthesis of geodin, the spirocoumaranone subunit of Sch 202596
Katoh، نويسنده , , Tadashi and Ohmori، نويسنده , , Osamu، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
An efficient synthesis of (±)-geodin [(±)-2] corresponding to the spirocoumaranone subunit of Sch 202596 (1) was accomplished in a convergent manner by utilizing coupling reaction of the aryl aldehyde 5 with the aryl bromide 6 and oxidative spirocyclization of the benzophenone 4 as the key steps. The aromatic segments 5 and 6 were prepared from commercially available methyl 3,5-dihydroxybenzoate (7) and 5-methylresorcinol (8), respectively.
coupling reactions , cyclization , biomimetic reactions , spiro compounds , antibiotics
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