Record number :
1636043
Title of article :
New accesses to l-iduronyl synthons
Author/Authors :
Lubineau، نويسنده , , A and Gavard، نويسنده , , O and Alais، نويسنده , , David Bonnaffé، نويسنده , , D، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Pages :
5
From page :
307
To page :
311
Abstract :
(PhS)3CLi adds with a total l-ido selectivity onto 3-O-benzyl-1,2-O-isopropylidene-α-d-xylo-dialdose 2, opening the way to the most efficient preparation of 1,2,4-tri-O-acetyl-3-O-benzyl-l-iduronyl synthon 8. Alternatively, in view of combinatorial syntheses, aldehyde 2 allows a good access to vinylic l-ido and d-gluco synthons which may be converted into uronic acid by a sequence involving a new aldehyde oxidation by m-CPBA in aqueous solution.
Keywords :
Organometallic , glycosaminoglycans , Oxidation , l-idose , l-iduronic acid , HEPARIN
Journal title :
Tetrahedron Letters
Link To Document :