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Title of article :
Survival of priceless cells: Active and passive protection of embryonic stem cells against immune destruction
Author/Authors :
Utermِhlen، نويسنده , , Olaf and Krِnke، نويسنده , , Martin، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
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Abstract :
This review focusses on our current knowledge of the mechanisms employed by embryonic stem (ES) cells to avoid destruction by cell-mediated immune responses. Recently, ES cells have been found to shield themselves against cytotoxic effector cells by expressing CD95L and serine protease inhibitor SPI-6 mediating apoptosis of the cytotoxic cells and inactivation of granzyme B, respectively. These findings are discussed in view of their implications for using ES cell-derived transplants in regenerative medicine as well as for our understanding of early embryonic stages during invasion and implantation.
Keywords :
Embryonic stem cells , Transplant rejection , resistance , Cytotoxic T cells , FasL , Serpin
Journal title :
Archives of Biochemistry and Biophysics
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Link To Document :